Informacije o izabranom projektu

Naziv projekta: / Akronim:
Nove metode za stratifikaciju rizika za progresiju kancera i Alchajmerove bolesti kod pacijenata u Crnoj Gori/DEMONSTRATE
Siže projekta:
The average life expectancy has more than doubled since the beginning of the 20th century, and is now approaching the value of 70 years ( As this change is present globally, regardless of the level of socio-economic development of the country, there is a need for health systems to adapt to the needs of older patients. Carcinoma and Alzheimer's disease (AD) most often occur in the elderly population, which is one of the causes for the increase in their incidence. Colorectal adenocarcinoma (CAC) is one of the leading causes of death from malignant diseases with 1.23 million newly discovered cases per year in the world, while AD is the most common cause of dementia in the elderly, affecting more than 44 million people worldwide. The course of these diseases is often complicated by serious infections. In patients with CAC there is an increased risk of developing infections, especially in the early post-operative period, while AD is often complicated by pneumonia. These are the reasons that put both of the diseases among the leading research priorities in developed countries. In accordance with these trends, the Strategy for the Development of Scientific Research Activity 2017-2021 of the Ministry of Science of Montenegro focuses on the research of chronic diseases whose incidence shows tendency of growth ( It is important to point out that some studies showed that the incidence of AD and cancer show inverse correlation - in people with cancer, the incidence of AB is very low, and vice versa - in people with AD incidence of cancer is very low (van der Wilik et al 2018). It is assumed that the same signalling pathways are deregulated in the opposite direction in these two diseases, pointing to a possible cross-talk between the molecular bases of either disease. However, there are no clear explanations of this phenomenon at the molecular level. The main goal of this project is to use new methods to improve the stratification of CAC patients and patients with AD disease according to the risk for progression of these diseases. This will help assignment of appropriate therapeutic modalities, thereby improve the quality of life, survival rate, decrease of complications and, in some cases could improve the chances for cure. In order to achieve this goal, we plan to use the following 3 multidisciplinary approaches: 1) The Real-Time quantitative Polymerase Chain Reaction (RT-qPCR) technique will be used to determine selected circulating micro-RNA (miRNA) expression level in patients with CAC and AD, as well as to assess the presence of the genomic kRAS mutation in patients with CAC, 2) RT-qPCR technique will also be used to investigate the correlation between the level of mitochondrial DNA (mtDNA) damage-associated molecular patterns (DAMPs) in the blood plasma and the onset of systemic inflammatory response (SIRS) and multi organ dysfunction (MODS) in these two groups of patients in a case of infectious complications, 3) Information technologies will be applied to analyze specific changes in the spatial geometry of the microvascular network in patients with CAC and those with AD. In this way, we plan to tackle the challenge of improving the health care for one of the vulnerable categories of the population - the citizens of the older age, which is fully in line with the National Strategy for the Development of the Health Care System in Montenegro (http: //www.mzdravlja. Also, by introducing a precise molecular risk stratification methodology, using the latest knowledge in the field of medical biotechnology, we plan to provide an individualized approach in selection of the therapeutic approach for patients in Montenegro.
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