How Did the Plague End? Economic activity took only a few years to recover, as did West Indies and Latin America. In 1720, Yersinia pestis arrived at the port of Marseille from the Levant upon the merchant ship Grand-Saint-Antoine. The Great Plague, lasting from 1665 to 1666, was the last major epidemic of the bubonic plague to occur in England. By Staff Writer Last Updated Mar 29, 2020 4:37:53 AM ET There are several factors that are thought to have ended the plague, or Black Death, but the most important appears to be measures taken by people to quarantine themselves.  However, Marseille quickly recovered from the plague outbreak. The Great Plague of Marseilles was the last of the significant European outbreaks of bubonic plague . He proclaimed that April 26, 1877, would be the day set aside for Minnesotans to beseech the Lord to end the plague. The Black Death was an epidemic of bubonic plague, a disease caused by the bacterium Yersinia pestis that circulates among wild rodents where they live in great numbers and density. Though most of the people who died during the Great Plague lived in London, the plague also killed people in other areas of England. The Great Fire of London, which happened on 2-6 September 1666, may have helped end the outbreak by killing many of the rats and fleas who were spreading the plague. It’s a disease that was carried over to England on rats that were likely infected in Asia. The Great Plague was technically an outbreak of the bubonic plague. This great outburst of plague was the last recurrence of a pandemic of bubonic plague, following the devastating episodes which began in the early fourteenth century; the first known instance of bubonic plague in Marseille was the arrival of the Black Death in the autumn of 1347. The plague was caused by the Yersinia pestis bacterium, which is usually transmitted through the bite of an infected rat flea. Plague had been around in England for centuries but in 1665 the so-called Great Plague hit the country – though it was Stuart London that took the worst of the plague. This is the same disease that rampaged England and most of Europe in the mid 14th century, otherwise known as the Black Death. It is important to note that it is in this era, so clearly marked by the impact of the plague, when the large-scale construction of monasteries, churches and cathedrals peters out. This was the last major outbreak of the bubonic plague in London, and killed 100,000 Londoners- about 20% of the city's population. Consequently, it can be said that the black death is the reason the Middle Ages come to an end. The plague was only finally brought under control in 1666 when the Great Fire of London burned down the areas most affected by plague – the city slums inhabited by the poor. How did the Great Plague of London start? The idea is that there was a silver lining to the tragedy of the fire, as it ended the great plague that swept the city from 1665-66. Arriving in Marseille , France in 1720, the disease killed 100,000 people in the city and the surrounding provinces.