Harmon Northrop Morse first synthesized paracetamol via the reduction of p-nitrophenol with tin in glacial acetic acid in 1878; however, paracetamol was not used in medical treatment for another 15 years. The 4-nitrophenol was reduce to 4-aminophenol by a reducing agent. Metabolic acidosis is a common metabolic disturbance among the acutely/critically ill that has many possible causes. An inherited medical condition wherein the amino acid, phenylalanine accumulates in the body, caution is advised in individuals with Phenylketonuria. Paracetamol adsorption in acidic, neutral and basic media on three activated carbons with different chemistry surfaces was studied. in paracetamol overdose), or a glutathione deficiency, NAPQI reacts with cellular membrane molecules, causing acute hepatic necrosis. The 4-aminophenol was reacted with acetic anhydride and paracetamol was obtained. Methods: Paracetamol was exposed to different conditions according to International Conference on Harmonization guideline. HPLC analyses of pharmaceutical dosage forms containing analgesics and related compounds (acetylsalicyclic acid, paracetamol, propyphenazone, caffeine and chlorpheniramine) were performed on C 18 and cyano columns under reversed-phase conditions . Under normal conditions, NAPQI is detoxified by conjugation with glutathione to form cysteine and mercapturatic acid conjugates, which are then renally excreted. SYMPTOMS: Symptoms of overexposure to this compound include nausea, vomiting, cyanosis from methemoglobinemia, injury to the liver, kidneys, central nervous system and heart, circulatory collapse, drowsiness, confusion, liver tenderness, low blood pressure, cardiac arrhythmias, jaundice, acute renal failure, death due to liver necrosis, metabolic acidosis, hepatic damage and cirrhosis. Paracetamol was synthesized by nitrating phenol using sulfuric acid and sodium nitrate. Chewable or effervescent paracetamol (including oral forms and combination varieties) may contain artificial sweetener (such as aspartame). A granular activated carbon (GAC) was prepared from coconut shell; starting from this sample, an oxidized activated carbon (GACo) was obtained by treating the GAC with a boiling solution of 6 M nitric acid, so to generate a greater number of oxygenated surface groups. The para-isomer was separated from the ortho-isomer by fractional distillation. Paracetamol Generic Name: Acetaminophen INN: Paracetamol VA CLASSIFICATION Primary: CN103 Secondary: CN850 Note: For information on acetaminophen combinations that are used for antacid as well as analgesic effects, see Acetaminophen, Sodium Bicarbonate, and Citric Acid (Systemic). However, when there is insufficient glutathione (e.g.