Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress. Lieberman A, Lyons K, Levine J, Myerburg R. Parkinsonism Relat Disord. Epub 2008 Nov 5. Risk of Neuropsychiatric Adverse Effects of Lipid-Lowering Drugs: A Mendelian Randomization Study. COVID-19 is an emerging, rapidly evolving situation. Adverse effects of statin therapy: Perception vs. the evidence — focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract. While counterintuitive, antidepressants can have the inverse effect of increasing depression symptoms rather than reducing them. Front Psychiatry. We know that cholesterol plays an important role in the serotonin system, so statins used to lower cholesterol may lead to the occurrence of depression. Yet, new guidelines and research suggest that statins’ benefits do not apply to everyone. Areas covered: However, confounding data also exist refuting a positive effect of these drugs at elevating mood. Diagnosis and management of statin intolerance. Since antidepressants work by changing neurotransmitter levels in the brain, it's possible for the chemicals to become imbalanced, which can lead to more severe mood symptoms, including thoughts of suicide. 2018;19(8):674-687. doi: 10.2174/1389200219666180305143501. Get the latest public health information from CDC: Molero Y, Cipriani A, Larsson H, Lichtenstein P, D'Onofrio BM, Fazel S. Lancet Psychiatry. © Copyright 2018 Physicians Postgraduate Press, Inc. NLM 2014 Sep;124:174-9. doi: 10.1016/j.pbb.2014.06.006. Renshaw PF, Parsegian A, Yang CK, Novero A, Yoon SJ, Lyoo IK, Cohen BM, Carlezon WA Jr. Pharmacol Biochem Behav. This article shows that statins could lead to depression by lowering cholesterol and that we should draw attention to this in clinical application, especially for patients complicated with depressive symptoms or low serum cholesterol levels. Depression is a common malady associated with numerous chronic medical conditions such as coronary artery disease, hypertension, and diabetes. The safety and effectiveness of statins as treatment for HIV-dyslipidemia: the evidence so far and the future challenges. Depression and Statin Drug Use From thousands of reports I have seen a strong association between statin drug use and affective disorders of all kinds.  |  Am J Cardiovasc Drugs. This article reviews i) cholesterol function in the brain, ii) how low cholesterol can cause depression, iii) a brief introduction of the serotonin system and how low cholesterol can disturb it, iv) neurosteroids and how they may lead to depression, and v) some direct evidence that statins can cause depression as well as contradicting evidence. Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study. Eur J Cardiovasc Nurs. Epub 2013 Sep 19. NIH COVID-19 is an emerging, rapidly evolving situation. Although this article stresses depression and its most extreme form, suicide, other affective manifestations include hostility, aggressiveness, rage, combativeness, accident proneness and special proneness for use of addictive substances. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Preparation of this article included an extensive literature search of statins and depression using PubMed from 1972 to 2012. Get the latest research from NIH: There is evidence suggesting an antidepressant effect when statins are adjunctively co-prescribed with antidepressant medicines. Med Hypotheses. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: HHS 2019 Jul;33(7):685-694. doi: 10.1007/s40263-019-00633-3. Since the pathophysiology of depression involves inflammation, statins could have a role in the treatment of mood disorders and might become a pharmacotherapy option for patients experiencing depression.